Haloperidol Impurity 38 HCl CAS 52669-92-8 (free base)
| CAS No. | 52669-92-8 (free base) |
| Molecular Formula | C21H21ClFNO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Haloperidol Impurity 38 HCl (CAS 52669-92-8 (free base), C21H21ClFNOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Haloperidol Impurity 38 HCl (C21H21ClFNOHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H21ClFNO HCl |
| Molecular Weight | 394.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Haloperidol Standards
- Haloperidol Impurity 10 (CAS 100442-88-4)
- Haloperidol Decanoate EP Impurity H (CAS 1134807-34-3)
- Haloperidol-d4 (CAS 1189986-59-1)
- Haloperidol impurity 02 (CAS 121751-79-9)
- Haloperidol impurity 40 (CAS 1253910-15-4)
- Haloperidol pyridinium Chloride Impurity (CAS 125785-69-5)
- Haloperidol EP Impurity B (CAS 1391052-53-1)
- Haloperidol EP Impurity F (CAS 1391052-67-7)
Recommended Standards
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- (4-Bromo-6-chloropyridin-3-yl)boronic acid (CAS 957062-85-0)
- Sacubitril impurity 15 (CAS CATO-C4X-280915)
- N-(tetrahydro-1,1-dioxido-3-thienyl)-2-Furanmethanamine hydrochloride (1:1) (CAS 307519-75-1)
- rac-Hesperetin (CAS 69097-99-0)
- Sperm Peptide P10G (H-2424.0001) (CAS 137353-73-2)
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